Over the past half-century, two types of traditional therapies have gained popularity in non-surgical cancer treatment. These two types of therapy are chemotherapy and radiation therapy. In both these types of therapy, cancer cells are destroyed. And as a result of this side effect, the normal cells of the body also undergo rapid division.
Presently the aim is to bring such cancer therapy, through which the growth and spread of cancer can be stopped mainly through medicines. The goal of this targeted therapy is to completely rid the body of cancer cells without causing any damage to the normal cells.
Consultant Medical Oncologist at Karkinos Health Care Pvt. Ltd. Precision oncology is molecular and genomic profiling of tumors to identify targeted changes, says Shreya Mallik. This is increasing slowly now. And that has entered the core of clinical practice of the last decade. Precision medicine is called personalized oncology. Its main goal is to give the right drug at the right dose at the right time. With the application of precision oncology, advanced and metastatic patients can survive longer. This era of precision therapy is having a revolutionary impact on lung, breast, colorectal, melanoma, kidney, bladder and lymphoma malignancies.
Dr. Shreya Mallik
Identifying patients with oncogenic driver mutations provides the opportunity to utilize genomic information about individual tumors. In this, the right therapy will be found for advanced cancer patients. There are different parts of precision medicine. Examples include molecular tyrosine enzyme inhibitors, monoclonal antibodies, cell cycle inhibitors, immune checkpoint inhibitors (immunotherapy) and antibody-drug conjugates (ADCs) and CAR-T cell therapy.
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Targeted therapies, such as monoclonal antibodies and monoclonal tyrosine kinase inhibitors, interact with multiple targets on cancer cells. Again immunotherapy activates the immune system to remove cancer cells. Antibody-drug conjugates are a new type of cancer drugs. ADC was originally designed to differentiate between healthy and malignant cells. There will be no side effects even if the patient takes this medicine for a long time. It will be effective in the treatment of breast cancer, lymphoma and leukemia.
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